Zolpidem Tartrate

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Zolpidem Tartrate

Introducing zolpidem tartrate 10 mg, more commonly known under the brand name Ambien, this medicine is often prescribed in the UK. It was first synthesized by a group of researchers at the French pharmaceutical company Synthélabo Recherche in the early 1980s. Zolpidem tartrate is a sedative-hypnotic and falls into the non-benzodiazepine class of drugs, also known as Z-drugs. It comes in hard tablet form with a potency of 10mg and has been available in the UK since 1988.

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What is Zolpidem Tartrate Used for?

Zolpidem tartrate is primarily prescribed in the UK to address insomnia. This condition is also known as sleep deprivation and is characterized by the inability to fall/stay asleep. It can vary in duration and be short-term (acute) and long-term (chronic) lasting for months.

It may be caused by different factors including anxiety, stress, chronic pain, lifestyle factors and certain medications. Lack of sleep can lead to constant fatigue, irritation and impaired cognitive functions. Insomnia can result in reduced work and academic productivity, problems in relationships and chronic conditions.

Approximately 29% of UK citizens suffer from insomnia. This is according to a recent study conducted by the University of Bristol and published in the British Medical Journal. The overwhelming statistics on the prevalence of sleep deprivation and its detrimental impact highlight the necessity for a trusted solution.

Zolpidem tartrate is a reliable medication designed to treat insomnia. Sufficient rest results in a better mood, boosted daily productivity, enhanced health and improved overall life quality.

Does Zolpidem Tartrate Work?

Trying to find a solution for sleep issues, people often look for a reliable medication. Zolpidem tartrate has established itself as a trusted go-to solution for sleep disturbances. It addresses insomnia by soothing the racing thoughts and promoting sedation. It facilitates the onset of slumber and allows people to fall asleep faster.

Early morning awakening insomnia occurs namely in elderly patients. People with the condition wake up earlier than planned and are unable to fall back asleep, often resulting in sleepiness during the day. Zolpidem tartrate has shown effectiveness in prolonging the duration of sleep and stopping early morning awakenings.

Those who wake up frequently during the night can also benefit from this drug. Zolpidem tartrate enhances the quality of slumber by making it deeper. It reduces the frequency of awakenings allowing for a long and continuous rest. All in all, this medicine helps people enjoy deep and restorative sleep.

How Does Zolpidem Tartrate Work?

Zolpidem tartrate is a sedative-hypnotic agent that treats insomnia by acting on the central nervous system to help a patient sleep. Its mechanism of action involves the interaction with the GABA receptors, namely the GABA-A receptors.

Zolpidem tartrate acts by attaching to a particular site on the GABA-A receptor and thus intensifies the actions of the neurotransmitter GABA, which is the chief inhibitory neurotransmitter in the brain. This interaction raises the frequency of chloride channel openings and depolarization of neuronal membranes, which in turn cause sedative, anxiolytic, and muscle-relaxant effects.

Zolpidem tartrate does not work like a conventional benzodiazepine. It selectively binds to specific subtypes of the GABA-A receptor that include alpha-1 which is linked to sleep. This helps it to be effective in inducing sleep without some of the side effects that are associated with benzodiazepines such as excessive sedation and dependency.

The onset of action of Zolpidem tartrate may vary for different patients depending on their metabolism and whether it was taken on an empty stomach or not. On average, this medicine kicks in within 15-30 minutes. The duration of its effect may also depend on other medications being taken. Its sleep-promoting effect lasts for 6-8 hours on average.

Zolpidem Tartrate Dosage Instructions and Safety Considerations

When it comes to addressing insomnia with medications like zolpidem tartrate, it is important to ensure the safety of the treatment by sticking with the dosage instructions. They can be provided by a healthcare practitioner or found printed on the patient information leaflet. The dose may depend on individual variables such as age, gender and pre-existing medical conditions.

It is recommended to take a zolpidem tartrate with a glass of water before bedtime. It can be taken with or without food, although taking it with a snack can prevent a stomach upset. The dosage can be adjusted by a consulting physician or a general practitioner based on individual response to the drug. Exceeding its maximum daily dose can increase the exposure to side effects and is not advised.

Geriatric patients and people with liver problems may require a lower dose due to increased sensitivity and the likelihood of side effects. Prolonged use of zolpidem tartrate is associated with risks of developing tolerance and dependency.

Treatment should not last for longer than prescribed by a doctor (usually up to 4 weeks). It is not recommended to stop the intake abruptly since it may cause withdrawal syndrome. Instead, gradually taper the dosage off until it is no longer required.

Is Zolpidem Tartrate a Safe Choice?

Zolpidem tartrate has undergone a rigorous evaluation process before being marketed. It has met the safety and efficacy standards set by regulatory authorities and has proven to be safe for the majority of people. This medicine is licensed and approved by the FDA - the Food and Drug Administration. It is a regulatory body responsible for assessing and testing medications, vaccines, food and other products before they are sold to consumers.

Even though safe and effective, zolpidem tartrate may not be suitable for everyone. It can exacerbate certain pre-existing medical conditions and is contraindicated for some patients. Breastfeeding/pregnant women, people with severe respiratory disorders, a history of substance abuse, severe liver impairment and allergy/hypersensitivity to the drug should not take this medicine.

Mixing zolpidem tartrate with certain substances and medications may result in potentially dangerous complications. Is not recommended to combine it with CNS depressants including alcohol, benzodiazepines, opioids or muscle relaxants, antidepressants, antihistamines and anticonvulsants.

Before you buy zolpidem tartrate, it is advised to consult with a healthcare professional. The specialist will assess your medical condition, consider the medications being taken and determine if this treatment is suitable for you.

Side Effects of Zolpidem Tartrate

The treatment with zolpidem tartrate, like in the case of any other medication, is associated with certain side effects. They may occur if the dosage and usage instructions are not strictly followed. They are usually mild and manageable and not everyone may experience them.

It is recommended to stay hydrated to prevent possible headaches. OTC pain relievers can also be considered if they persist. It is advisable to avoid activities that require full attention and coordination if drowsiness or dizziness/vertigo occur. It is advised to allocate at least 7 hours of undisrupted sleep after taking the medicine to prevent the next-day drowsiness.

Taking zolpidem tartrate on an empty stomach can provoke gastrointestinal discomfort and nausea. Ingesting it with a snack can solve this problem. Cognitive impairment and allergic reactions comprise the list of extremely rare side effects.

If allergic reactions arise or any of these adverse reactions persist or get bothersome, it is recommended to consult with a general practitioner. The doctor will adjust the zolpidem tartrate dose or provide advice on how to combat them.

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Where to Buy Zolpidem Tartrate in the UK

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Last Reviewed: 05th November 2024
Next Review Due: December 2025

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